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Synthesis and Biological Evaluation of Phosphonate Derivatives as Autotaxin (ATX) Inhibitors

Autotaxin (ATX) is an autocrine motility factor that promotes cancer cell invasion, cell migration and angiogenesis. ATX, originally discovered as a nucleotide phosphodiesterase, is known now to be responsible for the lysophospholipid-preferring phospholipase D activity in plasma. As such, it cataly...

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מידע ביבליוגרפי
Main Authors: Cui, Peng, Tomsig, Jose L., McCalmont, William F., Lee, Sangderk, Becker, Christopher J., Lynch, Kevin R., Macdonald, Timothy L.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2007
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116752/
https://ncbi.nlm.nih.gov/pubmed/17257836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.12.114
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