Synthesis and Antimicrobial Evaluation of Nitazoxanide-Based Analogues: Identification of Selective and Broad Spectrum Activity

A library composed of Nitazoxanide-based analogues was synthesized and assayed for increased antibacterial efficacy against the pyruvate:ferredoxin oxidoreductase (PFOR) utilizing microorganisms Helicobacter pylori, Campylobacter jejuni and Clostridium difficile. Derivatives were found to recapitula...

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Main Authors: Ballard, T. Eric, Wang, Xia, Olekhnovich, Igor, Koerner, Taylor, Seymour, Craig, Salamoun, Joseph, Warthan, Michelle, Hoffman, Paul S., Macdonald, Timothy L.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089805/
https://ncbi.nlm.nih.gov/pubmed/21275058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201000475
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