Biological Activity of Modified and Exchanged 2-Amino-5-Nitrothiazole Amide Analogues of Nitazoxanide

Head group analogues of the antibacterial and antiparasitic drug Nitazoxanide (NTZ) are presented. A library of 39 analogues was synthesized and assayed for their ability to suppress growth of Helicobacter pylori, Campylobacter jejuni, Clostridium difficile and inhibit NTZ target pyruvate:ferredoxin...

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Main Authors: Ballard, T. Eric, Wang, Xia, Olekhnovich, Igor, Koerner, Taylor, Seymour, Craig, Hoffman, Paul S., Macdonald, Timothy L.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881195/
https://ncbi.nlm.nih.gov/pubmed/20488706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.04.126
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