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Synthesis and Evaluation of Amino-Modified α-GalCer Analogues

[Image: see text] α-GalCer analogues featuring a phytoceramide 3- and 4-amino group have been synthesized. A Mitsunobu reaction involving phthalimide was employed for the introduction of the amino groups at the 3- and 4-positions of suitable phytosphingosine-derived precursors. The influence of thes...

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Detalhes bibliográficos
Main Authors: Trappeniers, Matthias, Chofor, René, Aspeslagh, Sandrine, Li, Yali, Linclau, Bruno, Zajonc, Dirk M., Elewaut, Dirk, Van Calenbergh, Serge
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903208/
https://ncbi.nlm.nih.gov/pubmed/20518554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol100934z
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