Galactosylsphingamides: new α-GalCer analogues to probe the F’-pocket of CD1d

Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic α-galactosylceramide, they produce a vast amount of cytokines. Here we present a synthesis that allows swift modification of the phytosph...

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Publicado no:Sci Rep
Main Authors: Guillaume, Joren, Wang, Jing, Janssens, Jonas, Remesh, Soumya G., Risseeuw, Martijn D. P., Decruy, Tine, Froeyen, Mathy, Elewaut, Dirk, Zajonc, Dirk M., Calenbergh, Serge Van
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487351/
https://ncbi.nlm.nih.gov/pubmed/28655912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04461-7
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