Crystal Structures of Bovine CD1d Reveal Altered αGalCer Presentation and a Restricted A’ Pocket Unable to Bind Long-Chain Glycolipids

NKT cells play important roles in immune surveillance. They rapidly respond to pathogens by detecting microbial glycolipids when presented by the non-classical MHC I homolog CD1d. Previously, ruminants were considered to lack NKT cells due to the lack of a functional CD1D gene. However, recent data...

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Bibliografische gegevens
Hoofdauteurs: Wang, Jing, Guillaume, Joren, Pauwels, Nora, Van Calenbergh, Serge, Van Rhijn, Ildiko, Zajonc, Dirk M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2012
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479135/
https://ncbi.nlm.nih.gov/pubmed/23110152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047989
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