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Synthesis of C-5″ and C-6″-modified α-GalCer analogues as iNKT-cell agonists
Alpha-Galactosyl Ceramide (α-GalCer) is a prototypical synthetic ligand of invariant natural killer T (iNKT) cells. Upon presentation by the MHC class I-like molecule CD1d, this glycolipid stimulates iNKT cells to secrete a vast amount of both pro-inflammatory Th1 and anti-inflammatory Th2 cytokines...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4461518/ https://ncbi.nlm.nih.gov/pubmed/26003341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.04.068 |
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