Synthesis and biological evaluation of γ-aminophosphonates as potent, sub-type selective sphingosine 1-phosphate receptor agonists and antagonists

The synthesis of N-arylamide phosphonates and related arylether and arylamine analogues provided potent, subtype-selective agonists and antagonists of the five known sphingosine 1-phosphate (S1P) receptors (S1P(1–5)). To this end, the syntheses of phosphoserine mimetics - selectively protected and o...

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Hlavní autoři: Foss, Frank W., Snyder, Ashley H., Davis, Michael D., Rouse, Michael, Okusa, Mark D., Lynch, Kevin R., Macdonald, Timothy L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1963459/
https://ncbi.nlm.nih.gov/pubmed/17113298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2006.10.060
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