Characterization of a Sphingosine 1-Phosphate Receptor Antagonist Prodrug

Sphingosine 1-phosphate (S1P) is a phospholipid that binds to a set of G protein-coupled receptors (S1P(1)–S1P(5)) to initiate an array of signaling cascades that affect cell survival, differentiation, proliferation, and migration. On a larger physiological scale, the effects of S1P on immune cell t...

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Autori principali: Kennedy, Perry C., Zhu, Ran, Huang, Tao, Tomsig, Jose L., Mathews, Thomas P., David, Marion, Peyruchaud, Olivier, Macdonald, Timothy L., Lynch, Kevin R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2011
Soggetti:
Drug Discovery and Translational Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164350/
https://ncbi.nlm.nih.gov/pubmed/21632869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.181552
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