Asymmetric Synthesis of Conformationally Constrained Fingolimod Analogues—Discovery of an Orally Active Sphingosine 1-Phosphate Receptor Type-1 Agonist and Receptor Type-3 Antagonist

Compound 1 (FTY720, Fingolimod) represents a new generation of immunosuppressant that modulates lymphocyte trafficking by interacting with the S1P(1) receptor. Compound 1 also provides a template molecule for studying the molecular biology of S1P receptors and related enzymes (kinases and phosphatas...

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Hlavní autoři: Zhu, Ran, Snyder, Ashley H., Kharel, Yugesh, Schaffter, Lisa, Sun, Qin, Kennedy, Perry C., Lynch, Kevin R., Macdonald, Timothy L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895489/
https://ncbi.nlm.nih.gov/pubmed/17994678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm7010172
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