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Development of Amidine-Based Sphingosine Kinase 1 Nanomolar Inhibitors and Reduction of Sphingosine 1-Phosphate in Human Leukemia Cells

Sphingosine 1-phosphate (S1P) is a bioactive lipid that has been identified as an accelerant of cancer progression. The sphingosine kinases (SphKs) are the sole producers of S1P and thus SphK inhibitors may prove effective in cancer mitigation and chemosensitization. Of the two SphKs, SphK1 overexpr...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kennedy, Andrew J., Mathews, Thomas P., Kharel, Yugesh, Field, Saundra D., Moyer, Morgan L., East, James E., Houck, Joseph D., Lynch, Kevin R., Macdonald, Timothy L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119570/
https://ncbi.nlm.nih.gov/pubmed/21495716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2001053
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