Biosynthesis of Alkyl Lysophosphatidic Acid by Diacylglycerol Kinases

Por Gellett, Amanda M., Kharel, Yugesh, Sunkara, Manjula, Morris, Andrew J., Lynch, Kevin R.
Publicado em 2012

Effect of alkyl chain length on sphingosine kinase 2 selectivity

Por Knott, Kenneth, Kharel, Yugesh, Raje, Mithun R., Lynch, Kevin R., Santos, Webster L.
Publicado em 2012

Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors

Por Raje, Mithun R., Knott, Kenneth, Kharel, Yugesh, Bissel, Philippe, Lynch, Kevin R., Santos, Webster L.
Publicado em 2011

A rapid assay for assessment of sphingosine kinase inhibitors and substrates

Por Kharel, Yugesh, Mathews, Thomas P., Kennedy, Andrew J., Houck, Joseph D., Macdonald, Timohy L., Lynch, Kevin R.
Publicado em 2011

SPHINGOSINE KINASE TYPE 2 INHIBITION ELEVATES CIRCULATING SPHINGOSINE 1-PHOSPHATE

Por Kharel, Yugesh, Raje, Mithun, Gao, Ming, Gellett, Amanda M., Tomsig, Jose L., Lynch, Kevin R., Santos, Webster L.
Publicado em 2012

Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury

Por Jo, Sang-Kyung, Bajwa, Amandeep, Ye, Hong, Vergis, Amy L., Awad, Alaa S., Kharel, Yugesh, Lynch, Kevin R., Okusa, Mark D.
Publicado em 2008

Asymmetric Synthesis of Conformationally Constrained Fingolimod Analogues—Discovery of an Orally Active Sphingosine 1-Phosphate Receptor Type-1 Agonist and Receptor Type-3 Antagoni...

Por Zhu, Ran, Snyder, Ashley H., Kharel, Yugesh, Schaffter, Lisa, Sun, Qin, Kennedy, Perry C., Lynch, Kevin R., Macdonald, Timothy L.
Publicado em 2007

Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels

Por Kharel, Yugesh, Morris, Emily A., Congdon, Molly D., Thorpe, Steven B., Tomsig, Jose L., Santos, Webster L., Lynch, Kevin R.
Publicado no J Pharmacol Exp Ther (2015)

Structure–Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors

Por Congdon, Molly D., Kharel, Yugesh, Brown, Anne M., Lewis, Stephanie N., Bevan, David R., Lynch, Kevin R., Santos, Webster L.
Publicado no ACS Med Chem Lett (2016)

Structure-activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors

Por Congdon, Molly D., Childress, Elizabeth S., Patwardhan, Neeraj N., Gumkowski, James, Morris, Emily A., Kharel, Yugesh, Lynch, Kevin R., Santos, Webster L.
Publicado no Bioorg Med Chem Lett (2015)

Structure–Activity Relationship Studies and in Vivo Activity of Guanidine-Based Sphingosine Kinase Inhibitors: Discovery of SphK1- and SphK2-Selective Inhibitors

Por Patwardhan, Neeraj N., Morris, Emily A., Kharel, Yugesh, Raje, Mithun R., Gao, Ming, Tomsig, Jose L., Lynch, Kevin R., Santos, Webster L.
Publicado no J Med Chem (2015)

Synthesis and Biological Evaluation of Sphingosine Kinase Substrates as Sphingosine-1-Phosphate Receptor Prodrugs

Por Foss, Frank W., Mathews, Thomas P., Kharel, Yugesh, Kennedy, Perry C., Snyder, Ashley H., Davis, Michael D., Lynch, Kevin R., Macdonald, Timothy L.
Publicado em 2009

SPHINGOSINE KINASE TYPE 1 INHIBITION REVEALS RAPID TURNOVER OF CIRCULATING SPHINGOSINE 1-PHOSPHATE

Por Kharel, Yugesh, Mathews, Thomas P., Gellett, Amanda M., Tomsig, Jose L., Kennedy, Perry C., Moyer, Morgan L., Macdonald, Timothy L., Lynch, Kevin R.
Publicado em 2011

Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles

Por Houck, Joseph D., Dawson, Thomas K., Kennedy, Andrew J., Kharel, Yugesh, Naimon, Niels D., Field, Saundra D., Lynch, Kevin R., Macdonald, Timothy L.
Publicado no ACS Med Chem Lett (2016)

Development of Amidine-Based Sphingosine Kinase 1 Nanomolar Inhibitors and Reduction of Sphingosine 1-Phosphate in Human Leukemia Cells

Por Kennedy, Andrew J., Mathews, Thomas P., Kharel, Yugesh, Field, Saundra D., Moyer, Morgan L., East, James E., Houck, Joseph D., Lynch, Kevin R., Macdonald, Timothy L.
Publicado em 2011

Discovery, Biological Evaluation and Structure-Activity Relationship of Amidine-Based Sphingosine Kinase Inhibitors

Por Mathews, Thomas P., Kennedy, Andrew J., Kharel, Yugesh, Kennedy, Perry C., Nicoara, Oana, Sunkara, Manjula, Morris, Andrew J., Wamhoff, Brian R., Lynch, Kevin R., Macdonald, Timothy L.
Publicado em 2010