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Effect of alkyl chain length on sphingosine kinase 2 selectivity

The conversion of sphingosine to sphingosine-1-phosphate is catalyzed by sphingosine kinase (SphK), which has been implicated in disease states such as cancer and fibrosis. Because SphK exists as two different isoforms, SphK1 and SphK2, understanding the physiological function of each isoenzyme is i...

詳細記述

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書誌詳細
主要な著者: Knott, Kenneth, Kharel, Yugesh, Raje, Mithun R., Lynch, Kevin R., Santos, Webster L.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394931/
https://ncbi.nlm.nih.gov/pubmed/22321213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.01.050
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