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Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors
Sphingosine kinase (SphK) has emerged as an attractive target for cancer therapeutics due to its role in cell survival. SphK phosphorylates sphingosine to form sphingosine 1-phosphate (S1P), which has been implicated in cancer growth and survival. SphK exists as two different isotypes, namely SphK1...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3748591/ https://ncbi.nlm.nih.gov/pubmed/22137932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.11.011 |
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