Structure–Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors

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• Structure-activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors
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• Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity
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• Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels
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