Structure–Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors

[Image: see text] The two isoforms of sphingosine kinase (SphK1 and SphK2) are the only enzymes that phosphorylate sphingosine to sphingosine-1-phosphate (S1P), which is a pleiotropic lipid mediator involved in a broad range of cellular processes including migration, proliferation, and inflammation....

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Xehetasun bibliografikoak
Argitaratua izan da:ACS Med Chem Lett
Egile Nagusiak: Congdon, Molly D., Kharel, Yugesh, Brown, Anne M., Lewis, Stephanie N., Bevan, David R., Lynch, Kevin R., Santos, Webster L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2016
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789682/
https://ncbi.nlm.nih.gov/pubmed/26985306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00304
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