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Structure–Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors
[Image: see text] The two isoforms of sphingosine kinase (SphK1 and SphK2) are the only enzymes that phosphorylate sphingosine to sphingosine-1-phosphate (S1P), which is a pleiotropic lipid mediator involved in a broad range of cellular processes including migration, proliferation, and inflammation....
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| Publicado no: | ACS Med Chem Lett |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2016
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4789682/ https://ncbi.nlm.nih.gov/pubmed/26985306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00304 |
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