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Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels
Sphingosine 1-phosphate (S1P) levels are significantly higher in blood and lymph than in tissues. This S1P concentration difference is necessary for proper lymphocyte egress from secondary lymphoid tissue and to maintain endothelial barrier integrity. Studies with mice lacking either sphingosine kin...
Enregistré dans:
| Publié dans: | J Pharmacol Exp Ther |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4576667/ https://ncbi.nlm.nih.gov/pubmed/26243740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.225862 |
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