Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels

Sphingosine 1-phosphate (S1P) levels are significantly higher in blood and lymph than in tissues. This S1P concentration difference is necessary for proper lymphocyte egress from secondary lymphoid tissue and to maintain endothelial barrier integrity. Studies with mice lacking either sphingosine kin...

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Bibliografiske detaljer
Udgivet i:J Pharmacol Exp Ther
Main Authors: Kharel, Yugesh, Morris, Emily A., Congdon, Molly D., Thorpe, Steven B., Tomsig, Jose L., Santos, Webster L., Lynch, Kevin R.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2015
Fag:
Cellular and Molecular
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576667/
https://ncbi.nlm.nih.gov/pubmed/26243740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.225862
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