Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles

[Image: see text] Sphingosine 1-phosphate (S1P) is a potent growth-signaling lipid that has been implicated in cancer progression, inflammation, sickle cell disease, and fibrosis. Two sphingosine kinases (SphK1 and 2) are the source of S1P; thus, inhibitors of the SphKs have potential as targeted ca...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Houck, Joseph D., Dawson, Thomas K., Kennedy, Andrew J., Kharel, Yugesh, Naimon, Niels D., Field, Saundra D., Lynch, Kevin R., Macdonald, Timothy L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867490/
https://ncbi.nlm.nih.gov/pubmed/27190598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00002
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