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Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist
Lysophosphatidic acid (LPA) is a bioactive compound that has gained attention due to its role in neoplastic diseases. Our group has developed a potent dual LPA1/LPA3 receptor antagonist, VPC51098 (LPA1 IC(50) = 84 nM, LPA1 IC(50) = 48 nM) that contained a labile phosphate head group. This lability h...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3237054/ https://ncbi.nlm.nih.gov/pubmed/22180836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C0MD00273A |
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