Nutrient Isothiocyanates Covalently Modify and Inhibit the Inflammatory Cytokine Macrophage Migration Inhibitory Factor (MIF)

Dietary isothiocyanates (ITCs) prevent cancer and show other bioactivities in vivo. As electrophiles, ITCs may covalently modify cellular proteins. Using a novel proteomics screen, we identified the Macrophage Migration Inhibitory Factor (MIF) as the principal target of nutrient ITCs in intact cells...

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Autores principales: Cross, Janet V., Rady, Joshua M., Foss, Frank W., Lyons, Charles, Macdonald, Timothy L., Templeton, Dennis J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858637/
https://ncbi.nlm.nih.gov/pubmed/19723024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20091170
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