Nutrient Isothiocyanates Covalently Modify and Inhibit the Inflammatory Cytokine Macrophage Migration Inhibitory Factor (MIF)

Dietary isothiocyanates (ITCs) prevent cancer and show other bioactivities in vivo. As electrophiles, ITCs may covalently modify cellular proteins. Using a novel proteomics screen, we identified the Macrophage Migration Inhibitory Factor (MIF) as the principal target of nutrient ITCs in intact cells...

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Bibliografiske detaljer
Main Authors: Cross, Janet V., Rady, Joshua M., Foss, Frank W., Lyons, Charles, Macdonald, Timothy L., Templeton, Dennis J.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858637/
https://ncbi.nlm.nih.gov/pubmed/19723024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20091170
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