Nutrient Isothiocyanates Covalently Modify and Inhibit the Inflammatory Cytokine Macrophage Migration Inhibitory Factor (MIF)

Dietary isothiocyanates (ITCs) prevent cancer and show other bioactivities in vivo. As electrophiles, ITCs may covalently modify cellular proteins. Using a novel proteomics screen, we identified the Macrophage Migration Inhibitory Factor (MIF) as the principal target of nutrient ITCs in intact cells...

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Bibliographic Details
Main Authors: Cross, Janet V., Rady, Joshua M., Foss, Frank W., Lyons, Charles, Macdonald, Timothy L., Templeton, Dennis J.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858637/
https://ncbi.nlm.nih.gov/pubmed/19723024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20091170
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