Conformationally Constrained Analogues of Diacylglycerol. 30. An Investigation of Diacylglycerol-lactones Containing Heteroaryl Groups Reveals Compounds with High Selectivity for R...

by Kazzouli, Saïd El, Lewin, Nancy E., Blumberg, Peter M., Marquez, Victor E.
Published 2008

Replacement of the Bryostatin A- and B-Pyran Rings With Phenyl Rings Leads to Loss of High Affinity Binding With PKC

by Petersen, Mark E., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M., Keck, Gary E.
Published in Tetrahedron Lett (2016)

Biochemical characterization of hyperactive β2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains

by Sosa, Maria Soledad, Lewin, Nancy E., Choi, Sung-Hee, Blumberg, Peter M., Kazanietz, Marcelo G.
Published 2009

Deletion of the C-26 Methyl Substituent from the Bryostatin Analogue Merle 23 has Negligible Impact on Its Biological Profile or Potency

by Zhao, Xiguang, Kedei, Noemi, Michalowski, Alexandra, Lewin, Nancy E., Keck, Gary E., Blumberg, Peter M.
Published in Chembiochem (2018)

Synthesis of protein kinase Cδ C1b domain by native chemical ligation methodology and characterization of its folding and ligand binding

by Ohashi, Nami, Nomura, Wataru, Kato, Mai, Narumi, Tetsuo, Lewin, Nancy E., Blumberg, Peter M., Tamamura, Hirokazu
Published 2009

The Bryostatin 1 A-Ring Acetate is Not the Critical Determinant for Antagonism of Phorbol Ester-Induced Biological Responses

by Keck, Gary E., Li, Wei, Kraft, Matthew B., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M.
Published 2009

Fluorescent-responsive Synthetic C1b Domains of Protein Kinase Cδ as Reporters of Specific High Affinity Ligand Binding

by Ohashi, Nami, Nomura, Wataru, Narumi, Tetsuo, Lewin, Nancy E., Itotani, Kyoko, Blumberg, Peter M., Tamamura, Hirokazu
Published 2010

Synthetic Caged DAG-lactones for Photochemically Controlled Activation of Protein Kinase C

by Nomura, Wataru, Narumi, Tetsuo, Ohashi, Nami, Serizawa, Yuki, Lewin, Nancy E., Blumberg, Peter M., Furuta, Toshiaki, Tamamura, Hirokazu
Published in Chembiochem (2011)

Membrane anchoring of diacylglycerol-lactones substituted with rigid hydrophobic acyl domains correlates with biological activities

by Raifman, Or, Kolusheva, Sofiya, Comin, Maria J., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M., Marquez, Victor E., Jelinek, Raz
Published 2009

Role of the C(8) gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity

by Keck, Gary E., Poudel, Yam B., Rudra, Arnab, Stephens, Jeffrey C., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M.
Published 2012

Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-Like Biology

by Ketcham, John M., Volchkov, Ivan, Chen, Te-Yu, Blumberg, Peter M., Kedei, Noemi, Lewin, Nancy E., Krische, Michael J.
Published in J Am Chem Soc (2016)

Critical Role of Trp-588 of Presynaptic Munc13-1 for Ligand Binding and Membrane Translocation

by Das, Joydip, Kedei, Noemi, Kelsey, Jessica S., You, Youngki, Pany, Satyabrata, Mitchell, Gary A., Lewin, Nancy E., Blumberg, Peter M.
Published in Biochemistry (2018)

Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones)

by Ann, Jihyae, Yoon, Suyoung, Baek, Jisoo, Kim, Da Hye, Lewin, Nancy E., Hill, Colin S., Blumberg, Peter M., Lee, Jeewoo
Published in Eur J Med Chem (2014)

Characterization of the Interaction of Phorbol Esters with the C1 Domain of MRCK (Myotonic Dystrophy Kinase-related Cdc42 Binding Kinase) α/β

by Choi, Sung Hee, Czifra, Gabriella, Kedei, Noemi, Lewin, Nancy E., Lazar, Jozsef, Pu, Yongmei, Marquez, Victor E., Blumberg, Peter M.
Published 2008

Conformationally Constrained Analogues of Diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the l...

by Kang, Ji-Hye, Peach, Megan L., Pu, Yongmei, Lewin, Nancy E., Nicklaus, Marc C., Blumberg, Peter M., Marquez, Victor E.
Published 2005

Synthesis of seco-B-Ring Bryostatin Analogue WN-1 via C–C Bond-Forming Hydrogenation: Critical Contribution of the B-Ring in Determining Bryostatin-like and Phorbol 12-Myristate 13...

by Andrews, Ian P., Ketcham, John M., Blumberg, Peter M., Kedei, Noemi, Lewin, Nancy E., Peach, Megan L., Krische, Michael J.
Published 2014

Synthesis of a des-B-Ring Bryostatin Analogue Leads to an Unexpected Ring Expansion of the Bryolactone Core

by Kraft, Matthew B., Poudel, Yam B., Kedei, Noemi, Lewin, Nancy E., Peach, Megan L., Blumberg, Peter M., Keck, Gary E.
Published 2014

Diacylglycerol Lactones Targeting the Structural Features That Distinguish the Atypical C1 Domains of Protein Kinase C ζ and ι from Typical C1 Domains

by Pu, Yongmei, Kang, Ji-Hye, Sigano, Dina M., Peach, Megan L., Lewin, Nancy E., Marquez, Victor E., Blumberg, Peter M.
Published in J Med Chem (2014)

Self-Assembly and Lipid Interactions of Diacylglycerol Lactone Derivatives Studied at the Air/Water Interface

by Philosof-Mazor, Liron, Volinsky, Roman, Comin, Maria J., Lewin, Nancy E., Kedei, Noemi, Blumberg, Peter M., Marquez, Victor E., Jelinek, Raz
Published 2008

Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol–Lactones as Protein Kinase C Ligands

by Ohashi, Nami, Kobayashi, Ryosuke, Nomura, Wataru, Kobayakawa, Takuya, Czikora, Agnes, Herold, Brienna K., Lewin, Nancy E., Blumberg, Peter M., Tamamura, Hirokazu
Published in Bioconjug Chem (2017)