Localizing a gate in CFTR

gan Gao, Xiaolong, Hwang, Tzyh-Chang
Cyhoeddwyd yn Proc Natl Acad Sci U S A (2015)

Spatial positioning of CFTR’s pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathway

gan Gao, Xiaolong, Hwang, Tzyh-Chang
Cyhoeddwyd yn J Gen Physiol (2016)

Electrostatic tuning of the pre- and post-hydrolytic open states in CFTR

gan Zhang, Jingyao, Hwang, Tzyh-Chang
Cyhoeddwyd yn J Gen Physiol (2017)

The Fifth Transmembrane Segment of Cystic Fibrosis Transmembrane Conductance Regulator Contributes to Its Anion Permeation Pathway

gan Zhang, Jingyao, Hwang, Tzyh-Chang
Cyhoeddwyd yn Biochemistry (2015)

Gating of the CFTR Cl(−) channel by ATP-driven nucleotide-binding domain dimerisation

gan Hwang, Tzyh-Chang, Sheppard, David N
Cyhoeddwyd 2009

The CFTR Ion Channel: Gating, Regulation, and Anion Permeation

gan Hwang, Tzyh-Chang, Kirk, Kevin L.
Cyhoeddwyd 2013

Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle

gan Jih, Kang-Yang, Hwang, Tzyh-Chang
Cyhoeddwyd 2013

Nonequilibrium Gating of CFTR on an Equilibrium Theme

gan Jih, Kang-Yang, Hwang, Tzyh-Chang
Cyhoeddwyd yn Physiology (Bethesda) (2012)

Positional effects of premature termination codons on the biochemical and biophysical properties of CFTR

gan Yeh, Jiunn-Tyng, Hwang, Tzyh-Chang
Cyhoeddwyd yn J Physiol (2019)

Probing an Open CFTR Pore with Organic Anion Blockers

gan Zhou, Zhen, Hu, Shenghui, Hwang, Tzyh-Chang
Cyhoeddwyd 2002

Voltage-dependent flickery block of an open cystic fibrosis transmembrane conductance regulator (CFTR) channel pore

gan Zhou, Zhen, Hu, Shenghui, Hwang, Tzyh-Chang
Cyhoeddwyd 2001

Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation

gan Bai, Yonghong, Li, Min, Hwang, Tzyh-Chang
Cyhoeddwyd 2010

Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7)

gan Bai, Yonghong, Li, Min, Hwang, Tzyh-Chang
Cyhoeddwyd 2011

Cysteine Scanning of CFTR’s First Transmembrane Segment Reveals Its Plausible Roles in Gating and Permeation

gan Gao, Xiaolong, Bai, Yonghong, Hwang, Tzyh-Chang
Cyhoeddwyd 2013

The Relationship between Camp, Ca(2)+, and Transport of Cftr to the Plasma Membrane

gan Chen, Peng, Hwang, Tzyh-Chang, Gillis, Kevin D.
Cyhoeddwyd 2001

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

gan Tsai, Ming-Feng, Li, Min, Hwang, Tzyh-Chang
Cyhoeddwyd 2010

Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation

gan Jih, Kang-Yang, Sohma, Yoshiro, Hwang, Tzyh-Chang
Cyhoeddwyd 2012

On the mechanism of gating defects caused by the R117H mutation in cystic fibrosis transmembrane conductance regulator

gan Yu, Ying‐Chun, Sohma, Yoshiro, Hwang, Tzyh‐Chang
Cyhoeddwyd yn J Physiol (2016)

Curcumin and Genistein: the Combined Effects on Disease-associated CFTR Mutants and their Clinical Implications

gan Sohma, Yoshiro, Yu, Ying-Chun, Hwang, Tzyh-Chang
Cyhoeddwyd yn Curr Pharm Des (2013)

Synergistic Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Gating by Two Chemically Distinct Potentiators, Ivacaftor (VX-770) and 5-Nitro-2-(3-Phenylpropylamin...

gan Lin, Wen-Ying, Sohma, Yoshiro, Hwang, Tzyh-Chang
Cyhoeddwyd yn Mol Pharmacol (2016)