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Spatial positioning of CFTR’s pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathway

The structural composition of CFTR’s anion permeation pathway has been proposed to consist of a short narrow region, flanked by two wide inner and outer vestibules, based on systematic cysteine scanning studies using thiol-reactive probes of various sizes. Although these studies identified several o...

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Vydáno v:J Gen Physiol
Hlavní autoři: Gao, Xiaolong, Hwang, Tzyh-Chang
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845689/
https://ncbi.nlm.nih.gov/pubmed/27114613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201511557
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