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On the mechanism of gating defects caused by the R117H mutation in cystic fibrosis transmembrane conductance regulator
KEY POINTS: Two functional abnormalities of cystic fibrosis transmembrane conductance regulator (CFTR), a 25% reduction of the single‐channel conductance (g) and a ∼13‐fold lower open probability (P (o)), were found with the R117H mutation that is associated with mild forms of cystic fibrosis. Chara...
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| Publicado no: | J Physiol |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4908022/ https://ncbi.nlm.nih.gov/pubmed/26846474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271723 |
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