Dual Activity of Aminoarylthiazoles on the Trafficking and Gating Defects of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Caused by Cystic Fibrosis Mutations

A large fraction of mutations causing cystic fibrosis impair the function of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel by causing reduced channel activity (gating defect) and/or impaired exit from the endoplasmic reticulum (trafficking defect). Such defects need...

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Detalhes bibliográficos
Main Authors: Pedemonte, Nicoletta, Tomati, Valeria, Sondo, Elvira, Caci, Emanuela, Millo, Enrico, Armirotti, Andrea, Damonte, Gianluca, Zegarra-Moran, Olga, Galietta, Luis J. V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083174/
https://ncbi.nlm.nih.gov/pubmed/21383017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.184267
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