High-throughput screening identifies FAU protein as a regulator of mutant cystic fibrosis transmembrane conductance regulator channel

In cystic fibrosis, deletion of phenylalanine 508 (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel causes misfolding and premature degradation. One possible approach to reducing the detrimental health effects of cystic fibrosis could be the identification of...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Tomati, Valeria, Pesce, Emanuela, Caci, Emanuela, Sondo, Elvira, Scudieri, Paolo, Marini, Monica, Amato, Felice, Castaldo, Giuseppe, Ravazzolo, Roberto, Galietta, Luis J. V., Pedemonte, Nicoletta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5787799/
https://ncbi.nlm.nih.gov/pubmed/29158263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.816595
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