High-throughput screening identifies FAU protein as a regulator of mutant cystic fibrosis transmembrane conductance regulator channel

In cystic fibrosis, deletion of phenylalanine 508 (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel causes misfolding and premature degradation. One possible approach to reducing the detrimental health effects of cystic fibrosis could be the identification of...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Tomati, Valeria, Pesce, Emanuela, Caci, Emanuela, Sondo, Elvira, Scudieri, Paolo, Marini, Monica, Amato, Felice, Castaldo, Giuseppe, Ravazzolo, Roberto, Galietta, Luis J. V., Pedemonte, Nicoletta
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2018
Ämnen:
Molecular Bases of Disease
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5787799/
https://ncbi.nlm.nih.gov/pubmed/29158263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.816595
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