Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation

Cystic fibrosis (CF) is caused by mutations in the CFTR chloride channel. Deletion of phenylalanine 508 (F508del), the most frequent CF mutation, impairs CFTR trafficking and gating. F508del-CFTR mistrafficking may be corrected by acting directly on mutant CFTR itself or by modulating expression/act...

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Publicado no:Sci Rep
Main Authors: Tomati, Valeria, Sondo, Elvira, Armirotti, Andrea, Caci, Emanuela, Pesce, Emanuela, Marini, Monica, Gianotti, Ambra, Ju Jeon, Young, Cilli, Michele, Pistorio, Angela, Mastracci, Luca, Ravazzolo, Roberto, Scholte, Bob, Ronai, Ze’ev, Galietta, Luis J. V., Pedemonte, Nicoletta
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505316/
https://ncbi.nlm.nih.gov/pubmed/26183966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12138
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