Three-dimensional Reconstruction of Human Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Revealed an Ellipsoidal Structure with Orifices beneath the Putative Transmembrane Domain

The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is a membrane-integral protein that belongs to an ATP-binding cassette superfamily. Mutations in the CFTR gene cause cystic fibrosis in which salt, water, and protein transports are defective in various tissues. Here we...

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Main Authors: Mio, Kazuhiro, Ogura, Toshihiko, Mio, Muneyo, Shimizu, Hiroyasu, Hwang, Tzyh-Chang, Sato, Chikara, Sohma, Yoshiro
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573082/
https://ncbi.nlm.nih.gov/pubmed/18723516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803185200
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