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Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle

Vx-770 (Ivacaftor), a Food and Drug Administration (FDA)-approved drug for clinical application to patients with cystic fibrosis (CF), shifts the paradigm from conventional symptomatic treatments to therapeutics directly tackling the root of the disease: functional defects of the cystic fibrosis tra...

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Bibliografiske detaljer
Main Authors: Jih, Kang-Yang, Hwang, Tzyh-Chang
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600496/
https://ncbi.nlm.nih.gov/pubmed/23440202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215982110
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