Identifying the molecular target sites for CFTR potentiators GLPG1837 and VX-770

The past two decades have witnessed major breakthroughs in developing compounds that target the chloride channel CFTR for the treatment of patients with cystic fibrosis. However, further improvement in affinity and efficacy for these CFTR modulators will require insights into the molecular interacti...

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Bibliografiske detaljer
Udgivet i:J Gen Physiol
Main Authors: Yeh, Han-I, Qiu, Liming, Sohma, Yoshiro, Conrath, Katja, Zou, Xiaoqin, Hwang, Tzyh-Chang
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605684/
https://ncbi.nlm.nih.gov/pubmed/31164398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201912360
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