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Identifying the molecular target sites for CFTR potentiators GLPG1837 and VX-770
The past two decades have witnessed major breakthroughs in developing compounds that target the chloride channel CFTR for the treatment of patients with cystic fibrosis. However, further improvement in affinity and efficacy for these CFTR modulators will require insights into the molecular interacti...
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| Publicado no: | J Gen Physiol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6605684/ https://ncbi.nlm.nih.gov/pubmed/31164398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201912360 |
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