Gating of the CFTR Cl(−) channel by ATP-driven nucleotide-binding domain dimerisation

The cystic fibrosis transmembrane conductance regulator (CFTR) plays a fundamental role in fluid and electrolyte transport across epithelial tissues. Based on its structure, function and regulation, CFTR is an ATP-binding cassette (ABC) transporter. These transporters are assembled from two membrane...

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Detalhes bibliográficos
Main Authors: Hwang, Tzyh-Chang, Sheppard, David N
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2009
Assuntos:
Symposium Section Reviews: Chloride Channels: Insight into Function from Human Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697289/
https://ncbi.nlm.nih.gov/pubmed/19332488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.171595
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