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Regulation of CFTR Cl(−) channel gating by ATP binding and hydrolysis

Opening and closing of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(−) channel is regulated by the interaction of ATP with its two cytoplasmic nucleotide-binding domains (NBD). Although ATP hydrolysis by the NBDs is required for normal gating, the influence of ATP binding versus...

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Autori principali: Ikuma, Mutsuhiro, Welsh, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC27007/
https://ncbi.nlm.nih.gov/pubmed/10880569
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