Regulation of CFTR Cl(−) channel gating by ATP binding and hydrolysis
Opening and closing of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(−) channel is regulated by the interaction of ATP with its two cytoplasmic nucleotide-binding domains (NBD). Although ATP hydrolysis by the NBDs is required for normal gating, the influence of ATP binding versus...
Guardado en:
| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2000
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27007/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10880569/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.140220597 |
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