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Regulation of CFTR Cl(−) channel gating by ATP binding and hydrolysis

Opening and closing of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(−) channel is regulated by the interaction of ATP with its two cytoplasmic nucleotide-binding domains (NBD). Although ATP hydrolysis by the NBDs is required for normal gating, the influence of ATP binding versus...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Ikuma, Mutsuhiro, Welsh, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27007/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10880569/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.140220597
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