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Regulation of CFTR Cl(−) channel gating by ATP binding and hydrolysis
Opening and closing of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(−) channel is regulated by the interaction of ATP with its two cytoplasmic nucleotide-binding domains (NBD). Although ATP hydrolysis by the NBDs is required for normal gating, the influence of ATP binding versus...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC27007/ https://ncbi.nlm.nih.gov/pubmed/10880569 |
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