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Electrostatic tuning of the pre- and post-hydrolytic open states in CFTR

Cystic fibrosis transmembrane conductance regulator (CFTR) is an ion channel that couples adenosine triphosphate (ATP) hydrolysis at its nucleotide-binding domains to gating transitions in its transmembrane domains. We previously reported that the charge-neutralized mutant R352C shows two distinct o...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: Zhang, Jingyao, Hwang, Tzyh-Chang
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339510/
https://ncbi.nlm.nih.gov/pubmed/28242630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611664
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