Targeted Gene Addition of Microdystrophin in Mice Skeletal Muscle via Human Myoblast Transplantation

Por Benabdallah, Basma F, Duval, Arnaud, Rousseau, Joel, Chapdelaine, Pierre, Holmes, Michael C, Haddad, Eli, Tremblay, Jacques P, Beauséjour, Christian M
Publicado em 2013

Use of zinc-finger nucleases to knock out the WAS gene in K562 cells: a human cellular model for Wiskott-Aldrich syndrome

Por Toscano, Miguel G., Anderson, Per, Muñoz, Pilar, Lucena, Gema, Cobo, Marién, Benabdellah, Karim, Gregory, Philip D., Holmes, Michael C., Martin, Francisco
Publicado em 2013

Zinc-finger Nuclease Editing of Human cxcr4 Promotes HIV-1 CD4(+) T Cell Resistance and Enrichment

Por Yuan, Jinyun, Wang, Jianbin, Crain, Karen, Fearns, Colleen, Kim, Kenneth A, Hua, Kevin L, Gregory, Philip D, Holmes, Michael C, Torbett, Bruce E
Publicado em 2012

Disruption of the BCL11A Erythroid Enhancer Reactivates Fetal Hemoglobin in Erythroid Cells of Patients with β-Thalassemia Major

Por Psatha, Nikoletta, Reik, Andreas, Phelps, Susan, Zhou, Yuanyue, Dalas, Demetri, Yannaki, Evangelia, Levasseur, Dana N., Urnov, Fyodor D., Holmes, Michael C., Papayannopoulou, Thalia
Publicado no Mol Ther Methods Clin Dev (2018)

Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases

Por Moehle, Erica A., Rock, Jeremy M., Lee, Ya-Li, Jouvenot, Yann, DeKelver, Russell C., Gregory, Philip D., Urnov, Fyodor D., Holmes, Michael C.
Publicado em 2007

Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery

Por Wang, Jianbin, DeClercq, Joshua J., Hayward, Samuel B., Li, Patrick Wai-Lun, Shivak, David A., Gregory, Philip D., Lee, Gary, Holmes, Michael C.
Publicado no Nucleic Acids Res (2016)

Zinc finger nuclease-mediated CCR5 knockout hematopoietic stem cell transplantation controls HIV-1 in vivo

Por Holt, Nathalia, Wang, Jianbin, Kim, Kenneth, Friedman, Geoffrey, Wang, Xingchao, Taupin, Vanessa, Crooks, Gay M., Kohn, Donald B., Gregory, Philip D., Holmes, Michael C., Cannon, Paula M.
Publicado em 2010

Derivation and Characterization of a Simian Immunodeficiency Virus SIVmac239 Variant with Tropism for CXCR4

Por Del Prete, Gregory Q., Haggarty, Beth, Leslie, George J., Jordan, Andrea P. O., Romano, Josephine, Wang, Nathaniel, Wang, Jianbin, Holmes, Michael C., Montefiori, David C., Hoxie, James A.
Publicado em 2009

Genome editing for scalable production of alloantigen‐free lentiviral vectors for in vivo gene therapy

Por Milani, Michela, Annoni, Andrea, Bartolaccini, Sara, Biffi, Mauro, Russo, Fabio, Di Tomaso, Tiziano, Raimondi, Andrea, Lengler, Johannes, Holmes, Michael C, Scheiflinger, Friedrich, Lombardo, Angelo, Cantore, Alessio, Naldini, Luigi
Publicado no EMBO Mol Med (2017)

Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme

Por Wang, Jianbin, Friedman, Geoffrey, Doyon, Yannick, Wang, Nathaniel S., Li, Carrie Jiaxin, Miller, Jeffrey C., Hua, Kevin L., Yan, Jenny Jiacheng, Babiarz, Joshua E., Gregory, Philip D., Holmes, Michael C.
Publicado em 2012

Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4(+) T cells from HIV-1 infection

Por Didigu, Chuka A., Wilen, Craig B., Wang, Jianbin, Duong, Jennifer, Secreto, Anthony J., Danet-Desnoyers, Gwenn A., Riley, James L., Gregory, Phillip D., June, Carl H., Holmes, Michael C., Doms, Robert W.
Publicado em 2014

DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

Por Simsek, Deniz, Brunet, Erika, Wong, Sunnie Yan-Wai, Katyal, Sachin, Gao, Yankun, McKinnon, Peter J., Lou, Jacqueline, Zhang, Lei, Li, James, Rebar, Edward J., Gregory, Philip D., Holmes, Michael C., Jasin, Maria
Publicado em 2011

Absence of WASp Enhances Hematopoietic and Megakaryocytic Differentiation in a Human Embryonic Stem Cell Model

Por Toscano, Miguel G, Muñoz, Pilar, Sánchez-Gilabert, Almudena, Cobo, Marién, Benabdellah, Karim, Anderson, Per, Ramos-Mejía, Verónica, Real, Pedro J, Neth, Olaf, Molinos-Quintana, Agueda, Gregory, Philip D, Holmes, Michael C, Martin, Francisco
Publicado no Mol Ther (2016)

Homology-driven genome editing in hematopoietic stem and progenitor cells using zinc finger nuclease mRNA and AAV6 donors

Por Wang, Jianbin, Exline, Colin M., DeClercq, Joshua J., Llewellyn, G. Nicholas, Hayward, Samuel B., Li, Patrick Wai-Lun, Shivak, David A., Surosky, Richard T., Gregory, Philip D., Holmes, Michael C., Cannon, Paula M
Publicado no Nat Biotechnol (2015)

Differential impact of transplantation on peripheral and tissue-associated viral reservoirs: Implications for HIV gene therapy

Por Peterson, Christopher W., Wang, Jianbin, Deleage, Claire, Reddy, Sowmya, Kaur, Jasbir, Polacino, Patricia, Reik, Andreas, Huang, Meei-Li, Jerome, Keith R., Hu, Shiu-Lok, Holmes, Michael C., Estes, Jacob D., Kiem, Hans-Peter
Publicado no PLoS Pathog (2018)

Cancer translocations in human cells induced by zinc finger and TALE nucleases

Por Piganeau, Marion, Ghezraoui, Hind, De Cian, Anne, Guittat, Lionel, Tomishima, Mark, Perrouault, Loic, René, Oliver, Katibah, George E., Zhang, Lei, Holmes, Michael C., Doyon, Yannick, Concordet, Jean-Paul, Giovannangeli, Carine, Jasin, Maria, Brunet, Erika
Publicado em 2013

Robust ZFN-mediated genome editing in adult hemophilic mice

Por Anguela, Xavier M., Sharma, Rajiv, Doyon, Yannick, Miller, Jeffrey C., Li, Hojun, Haurigot, Virginia, Rohde, Michelle E., Wong, Sunnie Y., Davidson, Robert J., Zhou, Shangzhen, Gregory, Philip D., Holmes, Michael C., High, Katherine A.
Publicado em 2013

Efficient genome editing in hematopoietic stem cells with helper-dependent Ad5/35 vectors expressing site-specific endonucleases under microRNA regulation

Por Saydaminova, Kamola, Ye, Xun, Wang, Hongjie, Richter, Maximilian, Ho, Martin, Chen, HongZhuan, Xu, Ning, Kim, Jin-Soo, Papapetrou, Eirini, Holmes, Michael C, Gregory, Philip D, Palmer, Donna, Ng, Philip, Ehrhardt, Anja, Lieber, André
Publicado no Mol Ther Methods Clin Dev (2015)

Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases

Por Santiago, Yolanda, Chan, Edmond, Liu, Pei-Qi, Orlando, Salvatore, Zhang, Lin, Urnov, Fyodor D., Holmes, Michael C., Guschin, Dmitry, Waite, Adam, Miller, Jeffrey C., Rebar, Edward J., Gregory, Philip D., Klug, Aaron, Collingwood, Trevor N.
Publicado em 2008

Therapeutic gene editing in CD34(+) hematopoietic progenitors from Fanconi anemia patients

Por Diez, Begoña, Genovese, Pietro, Roman‐Rodriguez, Francisco J, Alvarez, Lara, Schiroli, Giulia, Ugalde, Laura, Rodriguez‐Perales, Sandra, Sevilla, Julian, Diaz de Heredia, Cristina, Holmes, Michael C, Lombardo, Angelo, Naldini, Luigi, Bueren, Juan Antonio, Rio, Paula
Publicado no EMBO Mol Med (2017)