Absence of WASp Enhances Hematopoietic and Megakaryocytic Differentiation in a Human Embryonic Stem Cell Model

The Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency caused by mutations in the WAS gene and characterized by severe thrombocytopenia. Although the role of WASp in terminally differentiated lymphocytes and myeloid cells is well characterized, its role in early hematopoietic dif...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Toscano, Miguel G, Muñoz, Pilar, Sánchez-Gilabert, Almudena, Cobo, Marién, Benabdellah, Karim, Anderson, Per, Ramos-Mejía, Verónica, Real, Pedro J, Neth, Olaf, Molinos-Quintana, Agueda, Gregory, Philip D, Holmes, Michael C, Martin, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817813/
https://ncbi.nlm.nih.gov/pubmed/26502776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.196
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