Zinc-finger Nuclease Editing of Human cxcr4 Promotes HIV-1 CD4(+) T Cell Resistance and Enrichment

HIV-1-infected individuals can harbor viral isolates that can use CCR5, as well as CXCR4, for viral entry. To genetically engineer HIV-1 resistance in CD4(+) T cells, we assessed whether transient, adenovirus delivered zinc-finger nuclease (ZFN) disruption of genomic cxcr4 or stable lentiviral expre...

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Main Authors: Yuan, Jinyun, Wang, Jianbin, Crain, Karen, Fearns, Colleen, Kim, Kenneth A, Hua, Kevin L, Gregory, Philip D, Holmes, Michael C, Torbett, Bruce E
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321595/
https://ncbi.nlm.nih.gov/pubmed/22273578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.310
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