Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases

HIV-1 entry requires the cell surface expression of CD4 and either the CCR5 or CXCR4 coreceptors on host cells. Individuals homozygous for the ccr5Δ32 polymorphism do not express CCR5 and are protected from infection by CCR5-tropic (R5) virus strains. As an approach to inactivating CCR5, we introduc...

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Main Authors: Wilen, Craig B., Wang, Jianbin, Tilton, John C., Miller, Jeffrey C., Kim, Kenneth A., Rebar, Edward J., Sherrill-Mix, Scott A., Patro, Sean C., Secreto, Anthony J., Jordan, Andrea P. O., Lee, Gary, Kahn, Joshua, Aye, Pyone P., Bunnell, Bruce A., Lackner, Andrew A., Hoxie, James A., Danet-Desnoyers, Gwenn A., Bushman, Frederic D., Riley, James L., Gregory, Philip D., June, Carl H., Holmes, Michael C., Doms, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077364/
https://ncbi.nlm.nih.gov/pubmed/21533216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002020
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