Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4(+) T cells from HIV-1 infection

HIV-1 entry into CD4(+) T cells requires binding of the virus to CD4 followed by engagement of either the C-C chemokine receptor 5 (CCR5) or C-X-C chemokine receptor 4 (CXCR4) coreceptor. Pharmacologic blockade or genetic inactivation of either coreceptor protects cells from infection by viruses tha...

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Detalhes bibliográficos
Main Authors: Didigu, Chuka A., Wilen, Craig B., Wang, Jianbin, Duong, Jennifer, Secreto, Anthony J., Danet-Desnoyers, Gwenn A., Riley, James L., Gregory, Phillip D., June, Carl H., Holmes, Michael C., Doms, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879906/
https://ncbi.nlm.nih.gov/pubmed/24162716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-08-521229
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