A Single Amino Acid Mutation in the Envelope Cytoplasmic Tail Restores the Ability of an Attenuated Simian Immunodeficiency Virus Mutant To Deplete Mucosal CD4(+) T Cells

Disruption of the conserved motif GYxxØ in the simian immunodeficiency virus (SIV) SIVmac239 envelope (Env) cytoplasmic tail resulted in a virus (ΔGY) that exhibited a high plasma peak but uniquely failed to acutely deplete mucosal CD4(+) T cells. Here, we show that ΔGY containing a flanking S727P m...

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Detalhes bibliográficos
Main Authors: Breed, Matthew W., Jordan, Andrea P. O., Aye, Pyone P., Sugimoto, Chie, Alvarez, Xavier, Kuroda, Marcelo J., Pahar, Bapi, Keele, Brandon F., Hoxie, James A., Lackner, Andrew A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838135/
https://ncbi.nlm.nih.gov/pubmed/24027336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02126-13
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