Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif

Deletion of Gly-720 and Tyr-721 from a highly conserved GYxxØ trafficking signal in the SIVmac239 envelope glycoprotein cytoplasmic domain, producing a virus termed ΔGY, leads to a striking perturbation in pathogenesis in rhesus macaques (Macaca mulatta). Infected macaques develop immune activation...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Breed, Matthew W., Elser, Samra E., Torben, Workineh, Jordan, Andrea P. O., Aye, Pyone P., Midkiff, Cecily, Schiro, Faith, Sugimoto, Chie, Alvarez-Hernandez, Xavier, Blair, Robert V., Somasunderam, Anoma, Utay, Netanya S., Kuroda, Marcelo J., Pahar, Bapi, Wiseman, Roger W., O'Connor, David H., LaBranche, Celia C., Montefiori, David C., Marsh, Mark, Li, Yuan, Piatak, Michael, Lifson, Jeffrey D., Keele, Brandon F., Fultz, Patricia N., Lackner, Andrew A., Hoxie, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580161/
https://ncbi.nlm.nih.gov/pubmed/26223646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01134-15
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