Loss of a Tyrosine-Dependent Trafficking Motif in the Simian Immunodeficiency Virus Envelope Cytoplasmic Tail Spares Mucosal CD4 Cells but Does Not Prevent Disease Progression

A hallmark of pathogenic simian immunodeficiency virus (SIV) and human immunodeficiency virus (HIV) infections is the rapid and near-complete depletion of mucosal CD4(+) T lymphocytes from the gastrointestinal tract. Loss of these cells and disruption of epithelial barrier function are associated wi...

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Main Authors: Breed, Matthew W., Jordan, Andrea P. O., Aye, Pyone P., Lichtveld, Cornelis F., Midkiff, Cecily C., Schiro, Faith R., Haggarty, Beth S., Sugimoto, Chie, Alvarez, Xavier, Sandler, Netanya G., Douek, Daniel C., Kuroda, Marcelo J., Pahar, Bapi, Piatak, Michael, Lifson, Jeffrey D., Keele, Brandon F., Hoxie, James A., Lackner, Andrew A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554169/
https://ncbi.nlm.nih.gov/pubmed/23152518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01928-12
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