Loss of a Tyrosine-Dependent Trafficking Motif in the Simian Immunodeficiency Virus Envelope Cytoplasmic Tail Spares Mucosal CD4 Cells but Does Not Prevent Disease Progression

A hallmark of pathogenic simian immunodeficiency virus (SIV) and human immunodeficiency virus (HIV) infections is the rapid and near-complete depletion of mucosal CD4(+) T lymphocytes from the gastrointestinal tract. Loss of these cells and disruption of epithelial barrier function are associated wi...

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Autores principales: Breed, Matthew W., Jordan, Andrea P. O., Aye, Pyone P., Lichtveld, Cornelis F., Midkiff, Cecily C., Schiro, Faith R., Haggarty, Beth S., Sugimoto, Chie, Alvarez, Xavier, Sandler, Netanya G., Douek, Daniel C., Kuroda, Marcelo J., Pahar, Bapi, Piatak, Michael, Lifson, Jeffrey D., Keele, Brandon F., Hoxie, James A., Lackner, Andrew A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554169/
https://ncbi.nlm.nih.gov/pubmed/23152518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01928-12
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