Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif

Deletion of Gly-720 and Tyr-721 from a highly conserved GYxxØ trafficking signal in the SIVmac239 envelope glycoprotein cytoplasmic domain, producing a virus termed ΔGY, leads to a striking perturbation in pathogenesis in rhesus macaques (Macaca mulatta). Infected macaques develop immune activation...

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Publicat a:J Virol
Autors principals: Breed, Matthew W., Elser, Samra E., Torben, Workineh, Jordan, Andrea P. O., Aye, Pyone P., Midkiff, Cecily, Schiro, Faith, Sugimoto, Chie, Alvarez-Hernandez, Xavier, Blair, Robert V., Somasunderam, Anoma, Utay, Netanya S., Kuroda, Marcelo J., Pahar, Bapi, Wiseman, Roger W., O'Connor, David H., LaBranche, Celia C., Montefiori, David C., Marsh, Mark, Li, Yuan, Piatak, Michael, Lifson, Jeffrey D., Keele, Brandon F., Fultz, Patricia N., Lackner, Andrew A., Hoxie, James A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580161/
https://ncbi.nlm.nih.gov/pubmed/26223646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01134-15
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