Genome editing for scalable production of alloantigen‐free lentiviral vectors for in vivo gene therapy

Lentiviral vectors (LV) are powerful and versatile vehicles for gene therapy. However, their complex biological composition challenges large‐scale manufacturing and raises concerns for in vivo applications, because particle components and contaminants may trigger immune responses. Here, we show that...

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Detalles Bibliográficos
Publicado en:EMBO Mol Med
Main Authors: Milani, Michela, Annoni, Andrea, Bartolaccini, Sara, Biffi, Mauro, Russo, Fabio, Di Tomaso, Tiziano, Raimondi, Andrea, Lengler, Johannes, Holmes, Michael C, Scheiflinger, Friedrich, Lombardo, Angelo, Cantore, Alessio, Naldini, Luigi
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666310/
https://ncbi.nlm.nih.gov/pubmed/28835507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708148
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