Phagocytosis-Shielded Lentiviral Vectors Improve Liver Gene Therapy in Non Human Primates

Liver-directed gene therapy for the coagulation disorder hemophilia showed safe and effective results in clinical trials using adeno-associated viral vectors to replace a functional coagulation factor, although some unmet needs remain. Lentiviral vectors (LV) may address some of these hurdles becaus...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Milani, Michela, Annoni, Andrea, Moalli, Federica, Liu, Tongyao, Cesana, Daniela, Calabria, Andrea, Bartolaccini, Sara, Biffi, Mauro, Russo, Fabio, Visigalli, Ilaria, Raimondi, Andrea, Patarroyo-White, Susannah, Drager, Douglas, Cristofori, Patrizia, Ayuso, Eduard, Montini, Eugenio, Peters, Robert, Iannacone, Matteo, Cantore, Alessio, Naldini, Luigi
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613847/
https://ncbi.nlm.nih.gov/pubmed/31118293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav7325
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